Wearing a mask correctly can help prevent the spread of infection but if worn for long periods daily, it can defiantly cause some discomfort.
Most people will develop some sore spots especially behind the back of your ears, other may get rashes or some sort of facial irritation making ones skin sensitive.
Do consider the material your mask is made from. Natural materials like organic cotton are less likely to cause irritation than synthetic fiber. Also choose a mask with a soft and adjustable elastic ear loop to ensure it fits your face comfortably.